Tesamorelin Dosing Guide:
Protocol, Reconstitution & Tracking

Complete evidence-based Tesamorelin dosing protocol for 2026. Updated reconstitution steps, injection guidance, and cycle protocols.

⚠️ Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a licensed healthcare provider before starting any peptide or medication protocol.

⚡ Tesamorelin Quick Reference

Common dose: 1,000–2,000 mcg | Frequency: Once daily before bed
Half-life: 26 minutes | Category: Growth Hormone / FDA-Approved
Injection sites: Subcutaneous, abdomen

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What is Tesamorelin?

Tesamorelin (Egrifta) is a synthetic GHRH analogue FDA-approved for reducing excess abdominal fat in HIV-positive patients with lipodystrophy. The most clinically studied GHRH analogue, with extensive trial data showing 10–15% reduction in visceral adipose tissue. Stimulates pulsatile GH release that targets visceral fat specifically. Also shows cognitive improvements in older adults. Preferred by physicians for anti-aging visceral fat protocols due to FDA approval and robust clinical data.

Benefits of Tesamorelin

FDA-approved — most clinically validated GHRH analogue
10–15% reduction in visceral belly fat
Increases GH and IGF-1
Improves cognitive function in older adults
Reduces cardiovascular risk markers
Extensive safety data from clinical trials

Dosing Protocols

Below are evidence-based Tesamorelin dosing protocols for different experience levels and goals. Always start at the lowest effective dose and assess tolerance before increasing.

Anti-Aging: 2 mg daily before bed. 26-week minimum for visceral fat.

Conservative: 1 mg daily for 6–12 months.

Stack: 2 mg tesamorelin + 200 mcg ipamorelin before bed.

Reconstitution Guide

Proper reconstitution is critical for accurate dosing. Follow these steps carefully:

Add 2 mL BAC water to 2 mg vial ≈ 1,000 mcg/mL

2 mg dose = 2.0 mL (use 3 mL syringe) | 1 mg = 1.0 mL

Dosing Reference Table

Use this table to determine your exact injection volume based on vial size and BAC water amount:

Vial Size	BAC Water	Concentration	Low Dose Vol	High Dose Vol
2 mg	2 mL	1,000 mcg/mL	1.0 mL	2.0 mL
2 mg	1 mL	2,000 mcg/mL	0.5 mL	1.0 mL

Injection Site Guide

Recommended sites: Subcutaneous, abdomen

Rotate injection sites to prevent scar tissue buildup. Clean the injection site with an alcohol swab before injecting. Use a 27-29 gauge insulin syringe for subcutaneous injections. Pinch the skin, insert needle at 45-90°, and inject slowly.

Storage Guidelines

Lyophilized (powder) form: Refrigerate at 36–46°F (2–8°C). Protect from light. Most peptides remain stable for 1–2 years unreconstituted.

Reconstituted solution: Refrigerate immediately after mixing. Use within 4 weeks typically. Do not freeze reconstituted peptides — this may damage the peptide structure.

Frequently Asked Questions

Q: What is Tesamorelin used for?

A: Reducing visceral belly fat, GH optimization, metabolic improvement. FDA-approved for HIV lipodystrophy.

Q: Safety?

A: FDA-approved with extensive data. Common effects: fluid retention, joint pain. Generally well-tolerated.

Q: vs Sermorelin?

A: Both GHRH analogues. Tesamorelin has more clinical data and specific visceral fat reduction evidence.

Q: Long-term use?

A: Clinical trial data supports 26–52 week use. Ongoing treatment needed to maintain visceral fat benefits.

Q: Will fat return after stopping?

A: Yes — visceral fat returns within ~12 weeks of stopping. Ongoing treatment required.

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Tesamorelin Dosing Guide:Protocol, Reconstitution & Tracking